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About the department:

The Department of Polymers and Organic Synthesis carries out research on the synthesis of polymers and polymer-inorganic hybrids of the magnetic core-polymer shell type and organic synthesis of compounds with biological activity. The subject of scientific interest are also intermolecular interactions investigated by spectroscopic methods with the use of computational methods. The following methods are used to assess the physicochemical properties of polymers and organic compounds: spectroscopic (NMR, MS, IR, Raman, UV-VIS-NIR, spectrofluorimetry), thermal (TGA, DSC), microscopic (TEM, SEM, AFM), chromatographic (MPLC , HPLC, Flash) and trubidimetry (UV-VIS), nitrogen porosimetry, CHNS elemental analysis, XRD, DLS and others.

 

The Department consists of three independent researchers:

dr hab. Agnieszka Z. Wilczewska, prof. UwB  - Head of the Department

     prof. dr hab. Ryszard Łaźny

     dr hab. Alina T. Dubis, prof. UwB

               Research and teaching staff:

               dr Karolina H. Markiewicz

               dr Iwona Misztalewska-Turkowicz

               dr Urszula Kiełczewska

               mgr Paweł Misiak

                        Engineering and technical staff:

                        dr Michał Sienkiewicz

                        dr Karol Wołosewicz

                       mgr Piotr Moczulski

                       mgr Barbara Seroka

                       mgr Joanna Wołosewicz

                                 and

                                 mgr Izabela Kurowska - Doctoral School of Exact and Natural Sciences

                                 mgr Dawid Szymczuk - Doctoral School of Exact and Natural Sciences

Research interests:

Scope of the research:

  • Well-defined and characterized polymer materials in terms of their physicochemical properties.
  • Synthesis and analysis of organic-inorganic hybrids containing a magnetic core and a polymer coating for biomedical applications and organic catalysis.
  • Synthesis and analysis of polymers containing fullerenes and other nanoparticles in their structure.
  • Synthesis and analysis of selective polymer sorbents capable of selective sorption of organic compounds and metal ions.
  • Modification of the physical properties of polymers (glass transition temperature, polarity, sensitivity to stimuli) and chemical properties.
  • Designing of materials in terms of their chemical selectivity and stability.
  • Methods of physical and chemical immobilization of functional groups as well as active compounds in polymer materials and on nanoparticles.
  • Researching the thermal properties of materials (Thermogravimetry, Differential Scanning Calorimetry).
  • Infrared spectroscopy - transmission and reflection techniques, Raman spectroscopy.
  • Conformational analysis using spectroscopic methods and theoretical calculations.
  • Study of intermolecular interactions with spectroscopic methods and the application of the QTAiM and NBO theories.
  • Synthesis and analysis of new organic conductors.

Implemented Grants:

"Zonal thermosensitive star polymers based on steroids and saccharides as modern drug delivery systems.", implementation period February 2021 - February 2024, PRELUDIUM 19 (2020/37/N/ST5/02140). Location: University of Bialystok. Head of the project - mgr Paweł Misiak.

"Two in one – novel fluorescent polymers for simultaneous imaging and drug delivery.", implementation period September 2020 - September 2024, OPUS 18 (2019/35/B/ST5/03391). Location: University of Bialystok. Head of the project - dr hab. Agnieszka Wilczewska, prof. UwB.

"Novel stimuli-responsive block copolymers for smart drug delivery systems.", implementation period March 2017 - February 2021, OPUS 11 (2016/21/B/ST5/01365). Location: University of Bialystok. Head of the project - dr hab. Agnieszka Wilczewska, prof. UwB.

"New nanoparticles with superparamagnetic properties as heterogenic palladium catalysts for reactions performed in water.", implementation period March 2017 - March 2020, PRELUDIUM 11 (2016/21/N/ST5/013/16). Head of the project - dr Iwona Misztalewska-Turkowicz.

"Polymer-stabilized magnetic nanoparticles (PSMNPs) for biomedical applications.", implementation period 2015 - 2016, International research project POLONIUM, Hubert Curien Program, No. 35550ZD. Location: University of Bialystok, Paul Sabatier University (Toulouse III). Head of the project: dr hab. Agnieszka Wilczewska, prof. UwB, prof. Mathias Destarac.

"Formation of new carbon nanotube-based ion-imprinted polymers (CNT-IIP).", implementation period 2015 - 2018, PRELUDIUM 7 (2014/13/N/ST5/01563). Location: University of Bialystok. Head of the project: dr Karolina H. Markiewicz.

 

Department of Polymers and Organic Synthesis and Laboratory of Modern Technologies for Synthesis and Analysis of Polymers BioNanoTechno UwB equipment: GPC/SEC gel chromatography, HPLC chromatography with DAD, DSC differential scanning calorimeter, TGA thermogravimeter. Melting point apparatus, UV-VIS-NIR spectrometer, nitrogen sorbometer, polarimeter with temperature attachment, polymer synthesis reactor, MPLC, gradient flash chromatography, isocratic flash chromatography, microdistillers, FT-IR spectrophotometer, Raman spectrometer, lyophilizer.

Head of the Department

Publications

2021

  1. W. Rumińska, K. H. Markiewicz, A. Z. Wilczewska, A. Nawrocka “Effect of oil pomaces on thermal properties of model dough and gluten network studied by thermogravimetry and differential scanning calorimetry” Food Chemistry, 358(2021) 129882-129891, IF = 6,306; MNISW – 200 (10.1016/j.foodchem.2021.129882)

  2. M. Kravets, I. Misztalewska-Turkowicz, V. Sashuk, “Plasmonic nanoprobes gauging the length and flexibility of α,ω-Alkanedicarboxylic acids with an optical readout”, Sensors and Actuators: B. Chemical, 343 (2021) 130083, IF – 7,10 MNISW – 140: (10.1016/j.snb.2021.130083)

  3. K. H. Markiewicz*, K. Niemirowicz-Laskowska*, D. Szymczuk, K. Makarewicz, I. Misztalewska-Turkowicz, P. Wielgat, A. M. Majcher-Fitas, S. Milewska, H. Car, A.Z. Wilczewska* „Magnetic particles with polymeric shells bearing cholesterol moieties sensitize breast cancer cells to low dose of doxorubicin” International Journal of Molecular Sciences, 2021, 22, 4898, IF – 4,556, MNISW – 140 (10.3390/ijms22094898)
  4. G. Sobczak, I. Misztalewska-Turkowicz, V. Sashuk “Photoswitching, Colloidal Stability, and Reversible Self-Assembly of Gold Nanoparticles Covered with Thiolated Donor-Acceptor Stenhouse Adducts”J. Phys. Chem. C, 125 (2021) 5306−5314, IF – 4,189, MNiSW – 140 (doi.org/10.1021/acs.jpcc.0c10595)

2020

  1. I. Misztalewska-Turkowicz*, O. Coutelier, M. Destarac*, Two Pathways of Thiolactone Incorporation into Polyurethanes andTheir One-Pot Double Postfunctionalization, Macromolecules, 2020, 53, 10785−10795, IF – 5,918, MNiSW – 140 (doi.org/10.1021/acs.macromol.0c01779)

  2. P. Misiak, K. Niemirowicz-Laskowska, K. H. Markiewicz*, I. Misztalewska-Turkowicz, P. Wielgat, I. Kurowska, G. Siemiaszko, M. Destarac, H. Car, A.Z. Wilczewska* “Evaluation of Cytotoxic Effect of Cholesterol End-Capped Poly(N-Isopropylacrylamide)s onSelected Normal and Neoplastic Cells” International Journal of Nanomedicine, 2020:15 7263-7278 IF – 5,115, MNiSW – 140. (doi.org/10.2147/IJN.S262582)

  3. M. Kravets, G. Sobczak, N. Rad, I. Misztalewska-Turkowicz, O. Danylyuk, V. Sashuk, Visual discrimination of aromatic acid substitution patterns by supramolecular nanocooperativity, Chem. Comm., 2020, 56, 8595-8598. IF – 5,996, MNiSW – 200, (doi.org/10.1039/D0CC03633A)

  4. P. Misiak*, K. H. Markiewicz, D. Szymczuk, A.Z. Wilczewska* "Polymeric Drug Delivery Systems Bearing Cholesterol Moieties: A Review" Polymers 2020, 12(11) 2620; IF - 3,426, MNISW - 100 (doi.org/10.3390/polym12112620)

  5. E. Regulska, A. Breczko, A. Basa, A.T. Dubis, Rare-Earth Metals-Doped Nickel Aluminate Spinels for Photocatalytic Degradation of Organic Pollutants, Catalysts 2020, 10(9), 1003, IF – 3,52, MNiSW – 100, (doi.org/10.3390/catal10091003)

  6. A.G. Veiko, S. Sekowski, E. A. Lapshina, A. Z. Wilczewska, K. H. Markiewicz, M. Zamaraeva, H. Zhaod, I. B. Zavodnik “Flavonoids modulate liposomal membrane structure, regulate mitochondrial membrane permeability and prevent erythrocyte oxidative damage|” Biochimica et Biophysica Acta (BBA) – Biomembranes 1862(11) (2020) 183442-183442, 183442, IF – 3,411 (3,905), MNISW – 100 (doi.org/10.1016/j.bbamem.2020).
  7. E. Piktel, K.H. Markiewicz, A.Z. Wilczewska, T. Daniluk, S. Chmielewska, K. Niemirowicz-Laskowska, J. Mystkowska, P. Paprocka, P. B. Savage, R. Bucki, ”Quantification of synergistic effects of ceragenin CSA-131 combined with iron oxide magnetic nanoparticles against cancer cells”,  International Journal of Nanomedicine, 2020:15 4573-4589, IF – 4.471 (5y 5.029), MNiSW – 140, (doi.org/10.2147/IJN.S255170)

  8. W. Rumińska, M. Szymańska-Chargot, D. Wiącek, A. Sobota, K.H. Markiewicz, A.Z. Wilczewska, A. Miś, A. Nawrocka, “FT-Raman and FT-IR studies of the gluten structure as a result of model dough supplementation with chosen oil pomaces”, Journal of Cereal Science, 93 (2020) 102961-102973, IF – 2,452, MNISW – 140 (doi.org/10.1016/j.jcs.2020.102961).

  9. K. Niemirowicz-Laskowska, J. Mystkowska, D. Łysik, S. Chmielewska, G. Tokajuk, I. Misztalewska-Turkowicz,  A.Z. Wilczewska, R. Bucki „Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles”, International Journal of Molecular Science, 2020, 21(6), 1979-1996, IF – 4,183, MNISW – 140 (doi.org/10.3390/ijms21061979).

  10. E. Piktel, U. Wnorowska, M. Cieśluk, P. Deptuła, S.V. Prasad, G. Król, B. Durnaś, A. Namiot, K.H. Markiewicz, K. Niemirowicz-Laskowska, A.Z. Wilczewska, P.A. Janmey, J. Reszeć, R. Bucki “Recombinant human plasma gelsolin stimulates phagocytosis while diminishing excessive inflammatory responses in mice with Pseudomonas aeruginosa sepsis”, International Journal of Molecular Sciences, 2020,21(7) IF – 4,183, MNISW – 140 (10.3390/ijms21072551).

  11. G. Świderski, S. Wojtulewski, M. Kalinowska, R. Świsłocka, A.Z. Wilczewska, A. Pietryczuk, A. Cudowski, W. Lewandowski, “The influence of selected transition metal ions on the structure, thermal and microbiological properties of pyrazine-2-carboxylic acid”, Polyhedron 175 (2020) 114173, IF – 2,284, MNiSW – 100. (doi.org/10.1016/j.poly.2019.114173)

2019

  1. A.Z. Wilczewska, A. Kosińska, I. Misztalewska-Turkowicz, A. Kubicka, K. Niemirowicz-Laskowska, K.H. Markiewicz, R. Bucki, G. Celichowski, B. Kalska-Szostko, B. Rudolf, „Magnetic nanoparticles bearing metallocarbonyl moiety as antibacterial and antifungal agents”, Applied Surface Science, 487 (2019) 601-609, IF – 5,155, MNiSW – 140.
  2. J.T. Polit, I. Ciereszko, A.T. Dubis, J. Lesniewska, A. Basa, K. Winnicki, A. Zabka, M. Audzei, Ł. Sobiech, A.Faligowska, G. Skrzypczak, J. Maszewski, Irrigation-Induced Changes in Chemical Composition and Quality of Seeds of Yellow Lupine(Lupinus luteus L.), Int. J. Mol. Sci., 20 (2019) 5521, IF – 4,18, MNiSW – 100.
  3. K. Wolosewicz, K. Podgorska, E. Rutkowska, R. Lazny, “Synthesis of Dicarbonyl Curcumin Analogues Containing the Tropane Scaffold” European Journal Of Organic Chemistry, 29 (2019) 4662-4674
  4. R. Bucki, K. Niemirowicz-Laskowska, P. Deptuła, A.Z. Wilczewska, P. Misiak, B. Durnaś, K. Fiedoruk, E. Piktel, J. Mystkowska, P.A. Janmey, “Susceptibility of microbial cells to the modified PIP2-binding sequence of gelsolin anchored on the surface of magnetic nanoparticles” Journal of Nanobiotechnology  (2019) 17:81, https://doi.org/10.1186/s12951-019-0511-1, IF – 5,345, MNiSW – 140
  5. E. Grądzka, J. Goclon, S.K. Das, A. Dubis, K. Winkler, Polymer network of graphene oxide with covalently attached 2-(4’-hydroxyphenyl)fulleropyrolidine and palladium: Synthesis, properties and theoretical studies. Material Science and Eng. B. 249 (2019) 114406, IF – 3,50, MNiSW – 100.
  6. E. Piktel, U. Wnorowska, M. Cieśluk, P. Deptula, K. Pogoda, I. Misztalewska-Turkowicz, P. Paprocka, K. Niemirowicz-Laskowska, A.Z. Wilczewska, P. A. Janmey, R. Bucki, “Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin” Journal of Nanobiotechnology, (2019) 17:22, doi.org/10.1186/s12951-019-0455-5, IF – 5,294, MNiSW – 140.
  7. A. Nodzewska, A. Wadolowska, K. Podgorska, D. Pawelski, R. Lazny, “Synthesis of Solid-phase Supported Chiral Amines and Investigation of Stereoselectivity of Aldol Reactions of Amine-free Tropinone Enolate”, Current Organic Chemistry, 23 (2019) 1867-1879
  8. S. Zięba, A. Dubis, P. Ławniczak, A. Gzella, K. Pogorzelec-Glaser, A. Łapiński, Effect of counter ions on physical properties of imidazole-based proton conductors" Electrochimica Acta, 306 (2019) 575-589, IF – 5,383, MNiSW - 100.
  9. S. Zięba, A. Dubis, A.K. Gzella,P. Ławniczak, K. Pogorzelec-Glaser,A. Łapiński, Toward a new type of proton conductors based on imidazole and aromatic acids, Phys. Chem. Chem. Phys., 21 (2019), 17152-17162, IF - 3,567, MNiSW - 100.
  10. E. Szymanska, R. Czarnomysy, J. Jacyna, A. Basa, A.Z. Wilczewska, M. Markuszewski, K. Winnicka “Could spray-dried microbeads with chitosan glutamate be considered as promising vaginal microbicide carriers? The effect of process variables on the in vitro functional and physicochemical characteristics” International Journal of Pharmaceutics, (2019) 568:118558, IF – 3,832, MNiSW – 100
  11. G. Świderski, A.Z. Wilczewska, R. Świsłocka, K.H. Markiewicz, W. Lewandowski, Thermal and spectroscopic study of zinc, manganese, copper, cobalt and nickel 2,3-pyrazinedicarboxylate, Polyhedron, 162 (2019) 293–302, IF – 2,057, MNiSW – 100.
  12. A. Mizera, S. J. Grabowski, P. Ławniczak, M. Wysocka-Żołopa, A.T. Dubis, A. Łapiński, A Study of the Optical, Electrical and Structural Properties of Poly(pyrrole-3,4-dicarboxylic acid), Polymer, 164 (2019), 142-153, IF - 3,771, MNiSW - 100.
  13. K. Winnicki, I. Ciereszko, J. Leśniewska, A.T. Dubis, A. Basa, A. Żabka, M. Hołota, Ł. Sobiech, A. Faligowska, G. Skrzypczak, J. Maszewski, J.T. Polit, Irrigation afects characteristics of narrow-leaved lupin (Lupinus angustifolius L.) seeds, Planta, 248 (2019), 1-16, IF - 3,060, MNiSW - 100.
  14. G. Świderski, H. Lewandowska, R. Świsłocka, S. Wojtulewski, L. Siergiejczyk, A.Z. Wilczewska, I. Misztalewska, Spectroscopic (IR, Raman, NMR), thermal and theoretical (DFT) study of alkali metal dipicolinates (2,6) and quinolinates (2,3), Arabian Journal of Chemistry, 12 (2019) 4414-4426, IF – 3,613; MNiSW - 70.
  15. K.H. Markiewicz*, I. Misztalewska, K. Niemirowicz, R. Bucki, A.M. Majcher, A.Z. Wilczewska*, Carbamohydrazonothioate-based polymer-magneticnanohybrids: fabrication, characterization and bactericidal properties, Arabian Journal of Chemistry, 12 (2019) 5187-5199, IF - 3,613; MNiSW - 70.
  16. A. Golonko, T. Pienkowski, R. Swislocka, R. Lazny, M. Roszko, W. Lewandowski, “Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system” European Journal Of Medicinal Chemistry, 167 (2019) 291-311

2018

  1. I. Misztalewska-Turkowicz, K. H. Markiewicz, M. Michalak, A.Z. Wilczewska, “NHC-copper complexes immobilized on magnetic nanoparticles: Synthesis and catalytic activity in the CuAAC reactions”. Journal of Catalysis, 362 (2018) 46-54, IF – 7,723, MNiSW – 45.
  2. A. Maleki, J. Rahimi, O.M. Demchuk, A.Z. Wilczewska, R. Jasiński “Green in water sonochemical synthesis of tetrazolopyrimidine derivatives by a novel core-shell magnetic nanostructure catalyst” Ultrasonics Sonochemistry, 43 (2018) 262-271, IF – 7,279, MNiSW – 45.
  3. K. Niemirowicz, K. Głuszek, E. Piktel , K. Pajuste, B. Durnaś, G. Król, A.Z. Wilczewska, P.A. Janmey, A. Plotenice, R. Bucki, Bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines, International Journal of Nanomedicine, 2018:13 3411–3424, IF – 4,471, MNiSW – 35.
  4. G. Świderski, M. Kalinowska, A.Z. Wilczewska, J. Malejko, W. Lewandowski, „Lanthanide complexes with pyridinecarboxylic acids – Spectroscopic and thermal studies”, Polyhedron, 150 (2018) 97–109, IF - 2,284, MNSW - 30.
  5. G. Świderski, AZ. Wilczewska, R. Świsłocka, M. Kalinowska, W. Lewandowski, Spectroscopic (IR, Raman, UV–Vis) study and thermal analysis of 3d-metal complexes with 4-imidazolecarboxylic acid, Journal of Thermal Analysis and Calorimetry, 2018, 134/ 1, 513-525, IF - 2,471, MNSW - 20.
  6. P. Misiak, A.T. Dubis, A. Łapiński, Does the Intramolecular Hydrogen Bond Affect the Spectroscopic Properties of Bicyclic Diazole Heterocycles?, J. Spectroscopy, (2018), doi.org/10.1155/2018/1048157, MNiSW - 15.

2017

  1. G. Tokajuk, K. Niemirowicz, P. Deptuła, E. Piktel, M. Cieśluk, A.Z. Wilczewska, J.R. Dąbrowski, R. Bucki, “Use of magnetic nanoparticles as a drug delivery system to improve chlorohexidine antimicrobial activity” International Journal of Nanomedicine 2017:12 7833-7846 IF – 4,300, MNiSW – 35.
  2. K. Niemirowicz, H. Car, A. Sadowska, M. Wątek, R. Krętowski, M. Cechowska-Pasko, A.Z. Wilczewska, J. Mystkowska, I. Kasacka, A. Torres, R. Bucki „Pharmacokinetics and Anticancer Activity of Folic Acid-Functionalized Magnetic Nanoparticles”. Journal of Biomedical Nanotechnology, 13(6) (2017), 665-677(13). IF- 4,521, MNiSW - 40
  3. A. Nawrocka, M. Szymańska-Chargot, A. Miś, A.Z. Wilczewska, K.H. Markiewicz, “Aggregation of gluten proteins in model dough after fibre polysaccharide addition”, Food Chemistry, 231 (2017) 51-60, IF – 4,052, MNiSW – 40
  4. A. Nawrocka, M. Szymańska-Chargot, A. Miś, A.Z. Wilczewska, K.H. Markiewicz, “Effect of dietary fibre polysaccharides on structure and thermal properties of gluten proteins – A study on gluten dough with application of FT-Raman spectroscopy, TGA and DSC”, Food Hydrocolloids, 69 (2017) 410-421, IF – 4,749, MNiSW – 45
  5. B. Bankiewicz, S. Wojtulewski, K.H. Markiewicz, A.Z. Wilczewska, “Carbamohyrazonothioate derivative – experimental and theoretical explorations of the crystal and molecular structure” Structural Chemistry, 28 (2017) 801-812, IF – 1,854, MNiSW - 25

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Older publications are listed on the websites of individual employees.

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