Bioanalysis

Head of the Department

prof. dr hab. Ewa Gorodkiewicz

Academic Staff

prof. dr hab. Zbigniew Figaszewski (profesor emerytowany)

dr hab. Izabela Dobrzyńska

mgr Łukasz Ołdak

Technicians

dr Anna Sankiewicz

mgr inż. Kazimierz Wojtulewski

PhD students

mgr Łukasz Ołdak

Publications

• Szachowicz-Petelska B., Łuczaj W., Wroński A., Jastrząb A.,Dobrzyńska I. The differentia effect of cannabidiol on the composition and physicochemical properties of keratinocyte and fibroblast membranes from psoriatic patients and healthy people. Membranes 2021, 11, 11;
• Oldak L., Sankiewicz A., Żelazowska-Rutkowska B., Cylwik B., Lukaszewski Z., Skoczylas M., Gorodkiewicz E., „Two SPRi biosensors for the determination of cathepsin S in blood plasma”, Talanta, 2021, 225, 121900 
• Dobrzyńska I., Szachowicz-Petelska B., Wroński A., Jarocka-Karpowicz I., Skrzydlewska E. Changes in the physicochemical properties of blood and skin cell membranes as a results of psoriasis vulgaris and psoriatic arthritis development. Int. J. Mol. Sci. 2020, 21, 9129;
• Łuczaj W., Dobrzyńska I., Wroński A., Domingues M.R., Domingues P., Skrzydlewska E. Cannabidiol-mediated changes to the phospholipid profile of UVB-irradiated keratinocytes from psoriatic patients. Int. J. Mol. Sci. 2020, 21, 6592; 
• Atalay S., Dobrzyńska I., Gęgotek A., Skrzydlewska E. Cannabidiol protects keratinocyte cell membranes following exposure to UVB and hydrogen peroxide. Redox Biology 2020, 36, 101613,
• Olchowik-Grabarek E., Sękowski S., Bitiucki M., Dobrzyńska I., Shlyonsky V., Ionova M., Burzyński P., Roszkowska A., Święcicka I., Abdulladjanova N., Zamaraeva M. Inhibition of interaction between Staphylococcus aureus α-hemolysin and erythrocytes membrane by hydrolysable tannins: structure-related activity study.,Scientific Reports2020, 10:11168, 
• I. Dobrzyńska, B. Szachowicz-Petelska, A.Pędzińska-Betiuk, Z. A. Figaszewski, E. Skrzydlewska: „Effect of hypertension and FAAH inhibitor treatment of rats with primary and secondary hypertension considering the physicochemical properties of erythrocytes. Toxicol. Mech Method., 2020, 4, 297-305. 
• Ewa Matuszczak, Izabela Cwalina, Marzena Tylicka, Katarzyna Wawrzyn, Magdalena Nowosielska, Anna Sankiewicz, Lukasz Oldak, Ewa Gorodkiewicz, Adam Hermanowicz, „Levels of MMP-1, MMP-2 and fibronectin in the saliva of patients planned for endodontic treatment or surgical extraction”, Journal of Clinical Medicine, 2020, 9,3971
• Falkowski P., Łukaszewski Z., Gorodkiewicz E., „Potential of Surface Plasmon  Resonance Biosensors in cancer detection”, Journal of Pharmaceutical and Biomedical Analysis, 2020, November 27, 113802, 
• Szymanska B., Lukaszewski Z., Gorodkiewicz E., An immunosensor for the determination of carcinoembryonic antigen by Surface Plasmon Resonance imaging, Analytical Biochemistry, 2020, 609,113964,
• Sekowski S., Olchowik-Grabarek, E., Wieckowska, W., Veiko A., Oldak L., Gorodkiewicz E., Karamov E., Abdulladjanova N., Mavlyanov S., Lapshina E., Zavodnik, I.B., Zamaraeva, M., Spectroscopic, Zeta-potential and Surface Plasmon Resonance analysis of interaction between potential anti-HIV tannins with different flexibility and human serum albumin, Colloids and Surfaces B: Biointerfaces, 2020, 194,111175.
• Szymanska B., Lukaszewski Z., Hermanowicz-Szamatowicz K., Gorodkiewicz E., A biosensor for determination of the circulating biomarker CA125/MUC16 by Surface Plasmon Resonance Imaging, Talanta, 2020, 206: 120-187.
• Marta Komarowska, Beata Szymańska, Łukasz Ołdak, Anna Sankiewicz, Ewa Matuszczak, Ewa Gorodkiewicz, Wojciech Debek, Robert Milewski, Adam Hermanowicz, Plasma level of laminin 5 and collagen IV in cryptorchidism, Advances in Medical Sciences, 2020, 65: 176–181.
• Tomasz Guszcz, Beata Szymańska, Robert Kozlowski, Zenon Lukaszewski, Pawel Laskowski and Ewa Gorodkiewicz, Plasma aromatase as a sensitive and selective potential biomarker of bladder cancer and its role in tumorigenesis, Oncology Letters, 2020, 19: 562-568.
• I. Dobrzyńska, B. Szachowicz-Petelska, A.Pędzińska-Betiuk, Z. A. Figaszewski, E. Skrzydlewska:„Effect of hypertension and FAAH inhibitor treatment of rats with primary and secondary hypertension considering the physicochemical properties of erythrocytes”Toxicol. Mech Method., 2020, 4: 297-305.
• Tokarzewicz A., Romanowicz L., Sankiewicz A., Hermanowicz A., Sobolewski K., Gorodkiewicz E.,A new analytical method for determination of cathepsin L based on the Surface Plasmon Resonance Imaging biosensor., Int.J Mol.Sci., 2019, 20: 2166.
• Matuszczak E., Komarowska M.D., Sankiewicz A., Oldak L., Gorodkiewicz E., Debek W., Milewski R., Tylicka M., Hermanowicz A., Plasma concentrations of matrix metalloproteinase type 1 and matrix metalloproteinase type 2 in boys with cryptorchidism and its lack of correlation with INSL3 and inhibinB, The Scandinavian Journal of Clinical & Laboratory Investigation, 2019, 79, 6: 412-418.
• B. Szachowicz-Petelska: “Changes in the lipid composition of biological membranes under the influence of endogenous and exogenous factors.” Bioelectrochemistry (Moscow) 2019, 84: 164-170.
• I. Dobrzyńska, B. Szachowicz-Petelska, J. Weresa, Z. A. Figaszewski, E. Skrzydlewska:„Changes in physicochemical properties of kidney cells membrane as a consequence of hypertension and treatment of hypertensive rats with FAAH inhibitor”Chem. Biol. Interact., 2019, 299: 52-58.
• Dobrzyńska I., Association equilibria of divalent ions on the surface of liposomes formed from phosphatidylcholine., Eur. Phys. J. E, 2019, 42: 3.
• Gorodkiewicz E., Lukaszewski Z., Surface Plasmone Resonance Biosensors, Austin Journal of Biosensors& Bioelectronics, 2019, 5(1), 1034.
• Matuszczak E., Tylicka M.,  Debek W.,  Sankiewicz A., Gorodkiewicz E., Hermanowicz A., Concentration of Proteasome in the Blood Plasma of Children with Acute Appendicitis, Before and After Surgery, and Its Correlation with CRP, World Journal of Surgery 2018, 42(7): 2259-2264.
• Sankiewicz A, Romanowicz L, Pyc M, Hermanowicz A, Gorodkiewicz E, “SPR imaging biosensor for the quantitation of fibronectin concentration in blood samples” J Pharm Biomed Anal. 2018, 150: 1-8.
• Dorota Toliczenko-Bernatowicz, Ewa Matuszczak ,Marzena Tylicka, Anna Sankiewicz, Marta Komarowska, Ewa Gorodkiewicz, Wojciech Debek, Adam Hermanowicz „20S proteasome in the blood plasma of boys cryptorchidism”  Journal of Endocrinological Investigation, 2018, 41(9): 1103-1106.
• Matuszczak E., Sankiewicz A. Gorodkiewicz E., Hermanowicz A., ”Determination of the concentration of cathepsin B by SPRI biosensor in children with appendicitis, and its correlation with proteasomes”  Advances in Clinical and Experimental Medicine, 2018, 27, 11: 1529-1534.
• Weremijewicz A, Matuszczak E, Sankiewicz A, Tylicka M, Komarowska M, Tokarzewicz A, Debek W, Gorodkiewicz E, Hermanowicz A,„Matrix metalloproteinase-2 and its correlation with basal membrane components laminin-5 and collagen type IV in burn patients measured with Surface Plasmon Resonance Imaging (SPRI) biosensors,” Burns, 2018, 44, 4: 931-940.
• A. Tokarzewicz, A.Onopiuk, T. Guszcz, E. Gorodkiewicz, "The utility of cystatin C as a potential bladder tumor biomarker confirmed by Surface Plasmon Resonance technique", Indian Journal of Medical Research, 2018, 147: 46-50.
• Dorota Toliczenko-Bernatowicz, Ewa Matuszczak ,Marzena Tylicka, Beata Szymańska, Marta Komarowska, Ewa Gorodkiewicz, Wojciech Debek, Adam Hermanowicz “Overexpression of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in boys with cryptorchidism”, PLoS ONE, 2018, 13(2): 1-10.
• Matuszczak E., Artur Weremijewicz, Marta Komarowska, Anna Sankiewicz, Diana Markowska, Wojciech Debek, Ewa Gorodkiewicz, Robert Milewski, Adam Hermanowicz, "Immunoproteasome in the plasma of pediatric patients with moderate and major burns, and its correlation with proteasome and UCHL1 measured by SPR imaging biosensors", Journal of Burn Care & Research, 2018, 39, 6: 948-953.
• I. Dobrzyńska, A. Gęgotek, E. Gajko, E. Skrzydlewska, Z. A. Figaszewski: „ Effect of rutin on the physicochemical properties of skin fibroblasts membrane disruption following UV radiation”Chem. Biol. Interact., 2018, 282: 29-35.
• Gorodkiewicz E., Lukaszewski Z. , Recent Progress in Surface Plasmon Resonance Biosensors (2016 to Mid-2018), Biosensors, 2018, 4, 132.
• Ołdak Ł., Gorodkiewicz E., Biosensory w diagnostyce medycznej, Przegląd Lekarski, 2018, 75(06), 291-297.

 PATENTS

• „Biosensor do oznaczania fibronektyny osoczowej z wykorzystaniem przeciwciała” P.412413 z dnia 24.01.2020, autorzy Gorodkiewicz E., Sankiewicz A.
• „Biosensor do oznaczania enzymu metaloproteinazy-1 z wykorzystaniem przeciwciała” P.412411 z dnia 21.01.2020 autorzy Gorodkiewicz E., Tokarzewicz A.
• „Biosensor do oznaczania kolagenu typu IV z wykorzystaniem przeciwciała”, P.412412 a dnia 21.01.2020, autorzy Gorodkiewicz E., Sankiewicz A.
• „Biosensor do oznaczania stężenia enzymu katepsyny L”, nr P 422097 z dnia 17.10.2019 autorzy  Gorodkiewicz E., Tokarzewicz A., Hermanowicz A.
• „Biosensor do oznaczania Immunoproteasomu 20S z wykorzystaniem inhibitora” nr 417435 z dnia 4.06.2016 autorzy Gorodkiewicz E., Sankiewicz A.
• „Biosensor do oznaczania aromatazy z wykorzystaniem inhibitora” nr  P 398307 z dnia 5.03.2012 autorzy: Gorodkiewicz E., Laudański P.
• „Biosensor do oznaczania aromatazy z wykorzystaniem przeciwciała” nr  P 398306 z dnia 5.03.2012 autorzy: Gorodkiewicz E., Laudański P.
• „Biosensor do oznaczania podoplaniny” nr  P 397281 z dnia 8.12.2011 autorzy: Gorodkiewicz E., Charkiewicz R., Niklinski J., Łukaszewski Z.
• „Sensor zwłaszcza do akumulacji ilościowego oznaczania katepsyn”  nr  210052 z dnia 14.02.2008 autorzy: Gorodkiewicz E., Wojtulewski K., Łukaszewski Z.