Pharmaceutical and Food Analysis

1. The development of new selective analytical procedures for the isolation, concentration and determination of biologically active compounds (psychotropic, hypolipidemic, antifungal, antihistamine, α-blockers, antibiotics) and plant sterols in the environmental samples, pharmaceuticals and dairy food products. Modern extraction techniques (SPE, ME, LLE, SBSE, USAEME, DLLME) using designer solvents (IL, DES, SUPRAS), chromatographic (LC-MS/MS, HPLC-DAD, HPLC-CAD/FLD), spectroscopic and voltammetric methods for the isolation, separation and determination of these compounds.

2. The evaluation of the photostability of dyes, pharmaceuticals and other substances under simulated environmental conditions; identification of their metabolites employing chromatographic and chemometric methods.

3. Synthesis of the multifunctional composites based on inorganic semiconductors and carbon nanostructures of photo- and electrocatalytic properties.

Realized projects:

• dr Katarzyna Mielech-Łukasiewicz – grant NCN: MINIATURA 3 (2019/03/X/ST4/02089) „Ocena możliwości zastosowania modyfikowanej polipirolem  i cyklodekstrynami elektrody diamentowej domieszkowanej borem w analizie wybranych związków o właściwościach przeciwgrzybiczych” (2020-2021)
• dr Marta Hryniewicka, dr Ilona Kiszkiel-Taudul, dr Katarzyna Mielech-Łukasiewicz – project „Physico-chemical analysis of alcohol samples", realized under the EU project „Forge of WBCh Students competences”, the project is dedicated to 3rd year students of the first degree and 2nd year students of the second degree studies of Chemistry (2018-2020)
• dr Ilona Kiszkiel-Taudul – project BMN-161  „New solutions in the isolation of β-lactam and tetracycline antibiotics from food samples” (2018-2019)
• dr Marta Hryniewicka – project BMN-179  „Examination of the content of caffeic acid and its derivatives in medicinal plants” (2017-2018)
• dr Elżbieta Regulska – project BMN-180 „Preparation of the electrochemical sensor based on NiTiO­₃ decorated reduced graphene oxide for electrochemical glucose sensing in human body fluids” (2017-2018)
• dr Elżbieta Regulska – grant NCN: ETIUDA (2014/12/T/ST5/00118) „Novel nanocomposites based on titanium dioxide and fullerene’s derivatives as photoactive catalysts” (2014-2016)
• dr Elżbieta Regulska – grant NCN: PRELUDIUM (2012/05/N/ST5/01479) „Novel nanocomposites based on titanium dioxide and fullerene’s derivatives as photoactive catalysts” (2013-2016)
• dr hab. Barbara Starczewska, prof. UwB – grant GR-18 (NN305189435) „Studies of residues and evaluation of the photostability of selected drug groups in surface waters” (2008-2011)

Head of the Department

dr hab. Barbara Leśniewska

Academic Staff

dr hab. Barbara Marta Starczewska, prof. UwB

dr Marta Hryniewicka

dr Ilona Kiszkiel-Taudul

dr Katarzyna Mielech-Łukasiewicz

dr Elżbieta Regulska

dr Aneta Sokół

Technicians

mgr Anna Piasecka

Publications

Regulska E, Romero-Nieto C: Design of Organophosphorus Materials for Organic Electronics and Bio-applications, Materials Today Chemistry  2021, 22, 100604.

Romero-Nieto C, de Cózar A, Regulska E, Mullenix JB, Rominger F, Hindenberg P: Controlling the molecular arrangement of racemates through weak interactions: the synergy between π-interactions and halogen bonds, ChemComm  2021, 57, 7366-7369.

Regulska E, Breczko J, Rodziewicz P: Solvent effect on C₆₀ tris-acid solubility: Light scattering, spectroscopic, electrochemical and computational studes, Diamond and Related Materials 2021, 116, 108427.

Regulska E, Romero-Nieto C: Photoresponsive organophosphorus materials based on six-and seven-membered phosphorus heterocycles, in: S. Protti, C. Raviola (Ed.) Photochemistry: volume 48, RSC, 2021, pp.1376-410.

A. Sokół, A. Ratkiewicz, I. Tomaszewska, J. Karpińska; Kinetics and Mechanistic Studies of Photochemical and Oxidative Stability of Galaxolide, Water, 13, 2021, 1813.

M. Wawrzkiewicz, U. Kotowska, A. Sokół; Purification of Textile Effluents Containing C.I. Acid Violet 1: Adsorptive Removal versus Hydrogen Peroxide and Peracetic Acid Based Advanced Oxidation, Processes, 9(11), 2021, 1911.

K. Mielech-Łukasiewicz, M. Domalewska; Electrochemical determination of ciclopirox olamine by using boron-doped diamond electrode modified wit overoxidized polypyrrole film; Electrocatalysis, 12, 2021, 283-294.

I. Kiszkiel-Taudul; Determination of antihistaminic pharmaceuticals in surface water samples by SPE-LC-MS/MS method; Microchemical Journal, 162, 2021, 105874.

I. Kiszkiel-Taudul, B. Starczewska, A. Jabłońska; Ionic liquids based ultrasound assisted emulsification microextraction for determination of ranitidine in water samples and pharmaceutical preparations; New Journal of Chemistry, 44, 2020, 11490-11497.

M. Turkowicz, I. Jastrzebska, M. Hryniewicka, U. Kotowska, D. Gudalewska, J. Karpińska; Investigation of lipoic acid – 4-methoxybenzyl alcohol reaction and evaluation of its analytical usefulness; Food Chemistry, 309, 2020, 125750-125756.

M. Hryniewicka, B. Starczewska, N. Tkaczuk; Simple Approach Based On Ultrasound-Assisted Emulsification Microextraction For Determination Of β-Sitosterol In Dietary Supplements And Selected Food Products; Microchemical Journal, 155, 2020, 104775-104782.

E. Nalewajko-Sieliwoniuk, M. Hryniewicka, D. Jankowska, A. Kojło, M. Kamianowska, M. Szczepański; Dispersive liquid-liquid microextraction coupled to liquid chromatography tandem mass spectrometry for the determination of phenolic compounds in human milk, Author links open overlay panel; Food Chemistry 327, 2020, 126996-127003.

M. Lukasiewicz, J. Czerniecki, D. Ponikwicka‑Tyszko, M. Sztachelska, M. Hryniewicka, E. Nalewajko‑Sieliwoniuk, W. Wiczkowski, B. Banaszewska, R. Milewski, J. Toppari, I. Huhtaniemi, N. A. Rahman, S. Wolczynski; Placenta is Capable of Protecting the Male Fetus from Exposure to Environmental Bisphenol A; Exposure and Health, 2020, https://doi.org/10.1007/s12403-020-00358-5.

R. Motkowski, M. Maciejczyk, M. Hryniewicka, J. Karpińska, B. Mikołuć;  Effect of Statin Therapy on the Plasma Concentrations of Retinol, Alpha-Tocopherol and Coenzyme Q10 in Children with Familial Hypercholesterolemia;  Cardiovascular Drugs and Therapy, 2020, https://doi.org/10.1007/s12403-020-00358-5.

K. Mielech-Łukasiewicz, M. Leoniuk; Voltammetric determination of natamycin using a cathodically pretreated boron-doped diamond electrode in the presence of sodium dodecyl sulphate; Microchemical Journal 159, 2020,105570.

H.A.R.Tito, G. Hernandez-Sosa, C. Romero-Nieto, E. Regulska, N. Jurgensen, J. Zimmermann, K. Salazar-Salinas, M.E.Q. Caceda; Extraction of 2 '-O-apiosyl-6 '-O-crotonic acid-betanin from the ayrampo seed (Opuntia soehrensii) cuticle and its use as an emitting layer in an organic light-emitting diode; RSC Advances; 10, 2020, 36695–36703.

E. Regulska, P. Olejnik, H. Zubyk, J. Czyrko-Horczak, M.N. Chaur, M. Tomczykowa, O. Butsyk, K. Brzezinski, L. Echegoyen, M.E. Plonska-Brzezinska; Nanostructural catalyst: metallophthalocyanine and carbon nano-onion with enhanced visible-light photocatalytic activity towards organic pollutants; RSC Advances; 10, 2020, 10910–10920.

E. Regulska, J. Breczko, A. Basa, A.T. Dubis; Rare-earth metals-doped nickel aluminate spinels for photocatalytic degradation of organic pollutants; Catalysts, 10, 2020, 1003-1015.

E. Regulska, H. Ruppert, F. Rominger, C. Romero-Nieto; Synthesis of Blue-Luminescent Seven-Membered Phosphorus Heterocycles; Journal of Organic Chemistry, 85, 2020, 1247-1252.